The most common use of these peptides is to increase GH production. Other peptides in this category include GHRP-2, hexarelin, and ipamorelin. With regard to increasing GH, all of these work similarly, and there is no need or advantage to combining them. Instead, the one most suited for the particular case is chosen. GHRP-6 5mg (Growth Hormone Releasing Hexapeptide)
Growth hormone-releasing peptide 6 (GHRP-6) (developmental code name SKF-110679), also known as growth hormone-releasing hexapeptide, is one of several synthetic met-enkephalin analogues that include unnatural D–amino acids, were developed for their growth hormone-releasing activity and are called growth hormone secretagogues. They lack opioid activity but are potent stimulators of growth hormone (GH) release. These secretagogues are distinct from growth hormone releasing hormone (GHRH) in that they share no sequence relation and derive their function through activation of a completely different receptor. This receptor was originally called the growth hormone secretagogue receptor (GHSR), but due to subsequent discoveries, the hormone ghrelin is now considered the receptor’s natural endogenous ligand, and it has been renamed as the ghrelin receptor. Therefore, these GHSR agonists act as synthetic ghrelin mimetics.
It has been discovered that when GHRP-6 and insulin are administered simultaneously, GH response to GHRP-6 is increased (1). However, the consumption of carbohydrates and/or dietary fats, around the administration window of GH secretagogues significantly blunts the GH release.
In general, GHRP-6 is similar to GHRP-2. The main difference is that the latter is about 1.5 times more potent growth hormone booster along with increase in prolactin and cortisol concentrations. These peptides can be co-administered to achieve synergistic effect. Combined administration of GHRP-6 and GHRP-2 caused maximum growth hormone blood concentrations during studies. Although Hexarelin and GHRP-6 may be administered by various modes (i.e., subcutaneous, oral, sublingual and transbuccal ones), intramuscular route is the most common. Small molecules of this substance enable penetration through blood vessels of oral cavity and stomach prior to their degradation by digestive enzymes.